Wollenberg, A. et al. ETFAD/EADV Eczema Task Force 2020 Position paper on the diagnosis and treatment of atopic dermatitis in adults and children. J. Eur. Ldcc. Dermatol. Venereol. 34, 2717â2744 (2020). Schmitt, J. et al. The Harmonize Outcome Measures for Eczema (HOME) statement for the assessment of clinical signs of atopic eczema in studies. J.
Allergy Clin. Immunol. 134, 800â807 (2014). Brough HA, Liu AH, Sicherer S, Makinson K, Douiri A, Brown SJ, Stephens AC, Irwin McLean WH, Turcanu V, Wood RA, et al. Atopic dermatitis increases the effect of exposure to peanut antigens in dust on peanut sensitization and likely peanut allergy. J Allergy Clin Immunol. 2015;135(1):164–70. González-López G, Ceballos-Rodríguez RM, González-López JJ, Feito Rodríguez M, Herranz-Pinto P. Efficacy and safety of wet compress therapy in patients with atopic dermatitis: a systematic review and meta-analysis. Fr J Dermatol. 2017;177(3):688–95.
His medical history was also discreet, as he was completely born by vaginal delivery with an uncomplicated postnatal course. There have been no concerns about its size, weight or stages of development so far, and vaccinations have been up to date. There was a history of rhinitis in the father and mild dermatitis in his 2-year-old brother, but no other history of atopy in the family. Abraham, S. et al. Implementation of dupilumab in routine care of atopic eczema. Results of the German national register TREATgermany. Fr.
J. Dermatol. 183, 382â384 (2020). 5. Serrano L, Patel KR, Silverberg JI. Association between atopic dermatitis and extracutaneous bacterial and mycobacterial infections: a systematic review and meta-analysis. J am Acad Dermatol. 2019;80(4):904–912. Lane, J. E., Cheyney, J.M., Lane, T.
N., Kent, D. E. & Cohen, D. J. Treatment of unruly atopic dermatitis with omalizumab. J. Am. Ldcc. Dermatol.
54, 68-72 (2006). Bieber, T. Atopic dermatitis. N. Engl. J. 358, 1483â1494 (2008). Reich, K.
et al. Safety and efficacy of upadacitinib in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis (AD Up): Results of a randomized, double-blind, placebo-controlled Phase 3 study. Lancet 397, 2169â2181 (2021). Bieber T. Mechanisms of the disease: atopic dermatitis. 2008;358:1483–94. Bieber, T. et al. Elucidating the complexity of atopic dermatitis: the CK-CARE approach to precision medicine. Allergy 11, 2936â2938 (2020). Some patients may have several other common and benign skin conditions, such as pityriasis alba, a condition characterized by dry, pale spots on the face and upper arms, and keratosis pilaris, which is manifested by small, rough keratotic papules, especially on the upper arms and thighs. Atopic winter feet – plantar dermatitis sicca – a condition that usually occurs in school-aged children is characterized by symmetrical eczema on the weight areas of the soles of the feet.
Earlobe eczema, nipple eczema and eczema at the edge of the mouth (cheilitis) can be particularly troublesome and often involve infection with staphylococci. Keratoconus and cataracts sometimes complicate atopic dermatitis. Bieber, T. Atopic Dermatitis 2.0: From Clinical Phenotype to Molecular Taxonomy and Stratified Medicine. Allergy 67, 1475â1482 (2012). Kong, H. H. et al. Time changes in the skin microbiome associated with epidemics and treatment in children with atopic dermatitis. 22, 850â859 (2012).
Segal AO, Ellis AK, Kim HL. CSACI Statement: Safety of topical calcineurin inhibitors in the treatment of atopic dermatitis in children and adults. Allergy Asthma Clin Immunol. 2013;9(1):24. Kataoka, Y. Thymus and activation-regulated chemokine as a clinical biomarker in atopic dermatitis. J. Dermatol. 41, 221â229 (2014).
Birdi, G., Cooke, R. & Knibb, R.C. Effects of atopic dermatitis on quality of life in adults: a systematic review and meta-analysis. Int. J. Dermatol. 59, e75âe91 (2020). 11. Assessment of the severity of atopic dermatitis: the SCORAD index. Consensus report of the European Working Group on Atopic Dermatitis.
Dermatology. 1993;186(1):23–31. Barbeau M, Bpharm HL. Exposure to atopic dermatitis in Canada. Int J Dermatol. 2006;45(1):31–6. A cookie cutter skin biopsy may be required for patients with atypical presentations to rule out other skin conditions that may resemble AD. These conditions include other inflammatory dermatoses (seborrheic dermatitis, psoriasis, allergic or irritating contact dermatitis and pityriase lichenoids), primary ichthyosis, infestation (scabies), infections (fungus, human immunodeficiency virus [HIV]), malignant tumors (most commonly T-cell skin lymphoma), and metabolic disorders.19 Fungiid mycoses should be considered in patients with a rash that can look like an AD that occurs much later in life or completely. resistant to treatment. Serial biopsies may need to be performed for a definitive diagnosis if there is a high suspected index. If HIV is suspected, a serum enzyme immunosorbent assay for HIV should be performed.
Kabashima, K. et al. Nemolizumab in patients with moderate to severe atopic dermatitis: a randomized study of long-term phase II extension. J. Allergy Clin. Immunol. 142, 1121â1130 (2018). Several factors lead to the high heterogeneity of the age of onset of the disease in patients with AD, variations in clinical phenotype (especially in different ethnic origins) and the different risks of early development of an “aatopic walk” with atopic comorbidities (i.e. allergic rhinitis and asthma), neuropsychiatric comorbidities (anxiety, depression) or subsequent non-atopic (cardiovascular) comorbidities.
Diseases). . . . . .